Fig. 7. Malnutrition increases systolic arterial pressure and accelerates heart rate in rats aged 70 days: Losartan cancels the effects on systolic arterial pressure in malnourished rats, without affecting the heart rate. (A and C) Systolic arterial pressure (SAP). (B and D) Heart rate (HR). Empty bars, normonourished control rats (C); black bars, malnourished rats. Vertical dashed lines separate normonourished and malnourished groups in panels C and D. The left sections correspond to normonourished rats; the right sections correspond to malnourished rats. Abbreviations of the groups are indicated on the abscissae, according to the nutritional status and the timeline of pharmacological interventions with Losartan, Valproate or a combination of both drugs, as described in the text and in Supplementary Table 1. The data are mean ± SEM (n = 10-20). Differences were assessed by Student's t-test. The p values are indicated within the panels.